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Achtergrond 2018-07-09T18:17:32+00:00

Onze wetenschappelijke achtergrond blijkt uit de hieronder genoemde publicaties, rapporten en uitgevoerde projecten.

Publicaties

  • Results of oral versus intramuscular administration of high doses of MPA as a second or late line treatment in patients with advanced breast cancer. L. Beex, J. Burghouts, J. v. Turnhout, W. Breed, H. Hillen, A. Holdrinet, G. Boetius, G. Hoogendoorn, M. Verhulst, P. Meulenberg, E. Burghouts-Cammaert. ESMO Nice
  • Influence of aminoglutethimide on plasma levels of MPA: its correlation with serum cortisol. W.A.van Deijk, G.H. Blijham, W.A.M. Mellink & P.M.M. Meulenberg. Cancer Treatm. Rep. 69:85-90.
  • Studies on the input function of disodium cromoglycate in man. J.G. Houben, J. Festen, P.M.M. Meulenberg & J.M. van Rossum. IUPHAR 9th Int. Congress Pharmacol., London
  • Is there a correlation between plasma levels of disodium cromoglycate and its protective effect on exercise induced bronchoconstriction. Festen, J.J.G. Houben, H. Folgerink & P.M.M. Meulenberg. 19th Annual Meeting of SEPCR.
  • MPA administration to ovario-hypophysized, oestradiol-primed beagle bitches: effect on secretion of growth hormone, prolactine and cortisol. G.R. Rutteman, R. Stolp, A. Rijnkerk, S. Loeffler, J.A. Bakker, M.M. Bevers, P.M.M. Meulenberg & J.E. Eigenmann. Acta Endocrinol. 114:275-282.
  • Oral versus intramuscular administration of hogh dose medroxyprogesterone acetate in pretreated patients with advanced breast cancer. Beex, J. van Turnhout, W. Breed, H. Hillen, A. Hodrinet, G. Hoogendoorn, W. Doesburg, M. Verhulst and P. Meulenberg. Cancer Treatment Reports 71:1151, 1987.
  • The effect of oral contraceptives on plasma free and salivary cortisol and cortisone. P.M.M. Meulenberg, H.A. Ross, L.M.J.W. Swinkels & T.J. Benraad. Chim. Acta 165:379-385.
  • Salivary and plasma free testosterone and androstenedione levels in women using oral contraceptives containing desogestrel or levonorgestrel. L.M.J.W. Swinkels, P.M.M. Meulenberg, H.A. Ross, Th.J. Benraad. Clin. Biochem. 25:354-359, 1988.
  • The renin aldosterone system, progesterone and weight gain during normal pregnancy and the (patho)-physiological implications of chronic dietary sodium restriction. Steegers, T. Benraad, F. Derkx, M. Schalekamp, P. Meulenberg, R. de Bruin, P. Hein.
  • Salivary progesterone excellently reflects free and total progesterone in plasma during pregnancy. M.M. Meulenberg, J.A. Hofman. Clin. Chem. 35:168-172, 1989.
  • Total and free plasma cortisol and progesterone during pregnancy. P.M.M. Meulenberg. Proc.30th Dutch Fed. Meet. Abstract 257,1989.
  • Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum. M.M. Meulenberg, J.A. Hofman. Clin. Chem. 35:70 (1990)
  • The influence of salivary sample preparation on steroid hormone concentrations. M.M. Meulenberg, J.A. Hofman. J. Clin. Chem. Clin. Biochem.
  • The effect of oral contraceptive use and pregnancy on the daily rhythm of cortisol and cortisone. M.M. Meulenberg, J.A. Hofman. Clin. Chim. Acta 190:211-222 (1990).
  • Maternal testosterone and fetal sex. M.M. Meulenberg, J.A. Hofman. J. Steroid Biochem. 39:51-54 (1991).
  • Toepassing van de ANP bepaling. (Application of the ANP assay) P. Meulenberg; Toepassing van de Interleukin-6 bepaling. (Application of the Interleukin-6 assay) P. Meulenberg. Both articles where presented during the Medica beurs (Medical conference) in November 1990 and presented by J. A. Hofman and F. Rosmalen, ITS b.v., respectively.
  • Toepassing van de immunochemie in de waterkwaliteits-beheersing: Immuno-affiniteitschromatigrafie en ELISA van triazines in oppervlaktewater. (Application of immunochemistry for water quality control: Immuno-affinity chromatography and ELISA of triazines in surface water) W.H. Mulder, P.G.M. Stoks, J.A. Hofman, P. Meulenberg H2O 3:56-59 (1991).
  • Pyrethroids: A general overview of the use and toxicity of pyrethroid insecticides. A survey made for RIZA , Lelystad, the Netherlands.
  • The influence of altered hormonal status on the daily rhythm of corticosteroids in saliva. A lecture during the Symposium of the Investigation of Saliva in Würzburg, Germany.
  • Immunoassay product information: Survey (background and information concerning kits) about 6 hormones. Assignment of Nichols Institute Diagnostics in Wijchen, the Netherlands (1991).
  • Product information (on behalf of the International Distributor Meeting, Switzerland). Product information (background and information concerning kits) about 11 hormones. Assignment of Nichols Institute Diagnostics in Wijchen, the Netherlands (1991).
  • IGF-1: Method to method comparison of IGF-1 commercial assays. Survey on behalf of the presentation on the International Distributor Meeting, Switzerland. Assignment of Nichols Institute Diagnostics in Wijchen, the Netherlands (1991).
  • Source of priority substances: Survey into the production, use and emission of 40 organic priority micropollutants in the river Rhine, Meuse, IJsselmeer en Haringvliet. A report on behalf of RIWA, Amsterdam (1992).
  • Immunochemie en Milieu (Immunochemistry and Environment) An report on own account ELTI Support (1992).
  • Immunoassays: Application for water quality control. A report in cooperation with WRK en RIZA (1992).
  • Pesticides en Toxicity. C. Oosterhof & P. Meulenberg, a report on own account ELTI Support (1992).
  • Readjustment of the Priority-substances list, a report on behalf of RIWA, Amsterdam, the Netherlands (1993).
  • Manual for a workshop: The use of Immunoassays for water quality control, Andijk, the Netherlands (1993).
  • Application of immunoassay for water quality research. Meulenberg, P. Stoks, W-H. Mulder. H2O 26: 588-593 (1993).
  • Toxicity of pyrethroiden: Report on own account ELTI Support (1994)
  • Immunoassays for pesticides (Review). P. Meulenberg, W-H. Mulder, P. Stoks. Environmental Science and Technology 29(3):553-561 (1995).
  • Water quality control in the production of drinking water from river water. The application of immunological techniques for the detection of chlorophenoxy acid herbicides (2,4-D). Eline P. Meulenberg & Peter G. Stoks; Analytica Chimica Acta 311: 407-413 (1995).
  • Corticosteroids in saliva: new concepts on passage from plasma. Article on own account (see: Ph. D-thesis, 1995).
  • Immunochemical detection of environmental and food contaminations: Development, validation and application. P. Meulenberg. J. Environ-mental Food Biotechnology 35(3): 153-163 (1997).
  • Pesticides, Immunoassays. Eline P. Meulenberg. Encyclopaedia of Environmental Analysis and Remediation 1998, pp. 3505-3514.
  • Molecular Biology, Environmental Applications. Eline P. Meulenberg. Encyclopaedia of Environmental Analysis and Remediation 1998, pp. 2876-2882.
  • Investigation of indicative methods: Validation of several commercial ELISA´s for pesticides. Eline P. Meulenberg. Anal. Chim. Acta 399: 143-149 (1999).
  • Water quality control in the Netherlands: Selection and evaluation of indicative methods. P. Meulenberg, H. Niederlãnder, L. de Vree, J. Dogterom. Proceedings of the International Conference on Rapid Detection Assays for Food and Water, March 1999, CSL York, U.K.
  • Transport proteins in blood: A possible role in hormone disrupting effects of pollutants. In: Bioresponse-Linked Instrumental Analysis, B. Hock (ed.),Teubner-Reihe Umwelt, B.G. Teubner Stuttgart (2001) Chapter 6, pp. 131-151.
  • Water quality control in the Netherlands: Selection and evaluation of indicative methods. E.P. Meulenberg. In: Rapid Detection Assays for Food and Water. S.A. Clark, K.C. Thompson, C.W. Keevil, M.S. Smith, eds., RCS 2001, MPG Books Ltd., Cornwall, UK.
  • Effect of environmental pollutants as endocrine disruptors on human hormone binding proteins. J. Lipid Sci. Technol., 104: 131-136 (2002).
  • Targeted and rapid methods in analysing residues in food. E.P. Meulenberg, M.M. Rhemrev-Boom, C.G.J. Koopal. In: Pesticides, veterinary and other residues in food. D.H. Watson, ed., Woodhead Publ. Ltd., Cambridge, UK. (2004).
  • Immunoassays for (alkyl)phenolic pollutants with endocrine disrupting activity. P. Meulenberg, K. Koopal, R. Rhemrev. Int. J. Environ. Anal. Chem. 85: 871-883 (2005).
  • Immunochemical detection methods for bioactive pollutants. P. Meulenberg, G. Peelen, E. Lukkien, K. Koopal. Int. J. Environ. Anal. Chem. 85: 861-870 (2005).
  • Multiplex detection in the food production chain. J.H.W. Bergervoet, J. Peters, J.M. van der Wolf, W. Haasnoot, M.E. Bienenmann, J.G. du Pre, R. Wessels, E. Meulenberg. Poster at Rapid Methods Europe 2005, Noordwijk aan Zee, The Netherlands, 24-25 May 2005.
  • Rapid assays in pollution analysis: immunochemical techniques. In Analytical techniques for water analysis (submitted, 2005).
  • Rapid assays in pollution analysis: immunochemical techniques. In: Environmental Degradation and Protection, Volume I, K.K. Singh et al., eds., MD Publications Pvt Ltd., New Delhi; pp. 222-275, 2007.
  • Endocrine disrupting compounds in the environment.
    Eline P. Meulenberg, Invited book chapter, 2008, in press.
  • Phenolics: Occurence and immunochemical detection in environment and
    Eline P. Meulenberg, Molecules 13, 2008; submitted.
  • Obesitas: Een wereldwijd probleem. Deskresearch naar omgevingsfactoren / obesogenen die kunnen leiden tot obesitas.
    ELTI Support Rapport 2009.Download Obesitas-2c publicatie
  • Obesitas en therapie. Deskresearch naar nieuwe therapeutica voor de behandeling van obesitas.
    ELTI Support Rapport 2010.
  • Premature bevallingen: Deskresearch naar mogelijke omgevingsfactoren die kunnen leiden tot premature bevallingen.
    ELTI Support Rapport 2010.
  • Immunochemical methods for ochratoxin A detection: A review. Eline P. Meulenberg. Toxins 4: 244-266  (2012).
  • The development and application of ELISA for 3-indole-butyric acid. Eline P. Meulenberg. Immunochem. Immunopathol. 1: 104 (2015).
  • Salivary progesterone as a biomarker in pregnancy. Eline P. Meulenberg. Biochem. Anal. Biochem. 4 (2015).
  • Salivary progesterone as a biomarker in pregnancy. Eline P. Meulenberg. Top 10 Contributions on biochemistry, Chapter 3, www.avidscience.com. (2018).
  • The development and application of ELISA for 3-indole-butyric acid. Eline P. Meulenberg. Top 10 Contributions on immunology: 2nd Edition. Chapter 10, www.acidscience.com (2018).

Rapporten:

  • 1992 Applicability of cyclodextrines for sampling and purifying of surface water. A report made by ELTI Support on own account.
  • 1993 Screening of the 2,4-D-level in Rhine water by immunoassay: an evaluation study A report in order of WRK (Nieuwegein, the Netherlands).
  • 1994 Screening of the 2,4-D-level in Rhine water by immunoassay: application in the early-warning program. A report in order of WRK (Nieuwegein, the Netherlands).
  • 1994 Analyses of isoproturon in samples of surface water: a comparative investigation by immunoassay and LC-MS. In order of WRK (Nieuwegein, the Netherlands).
  • 1994 Readjusted list of priority-substances. Desk research in order of RIWA (Amsterdam, the Netherlands).
  • 1994 Immunoaffinity chromatography of pesticides: preliminary research with atrazine as a target compound. Report in the scope of a national cooperation project (IAC)
  • 1994 Applicability of the screening on 2,4-D in Rhine water by immunoassay. Report on a period of Practical Training.
  • 1995 Phenylurea herbicides screening in the Rhine. In order of WRK in Nieuwegein, the Netherlands. Report no. 1.
  • 1995 Immunoaffinity chromatography of pesticides: research into IAC-columns. Report on a period of Practical Training.
  • 1995 Pyrethroids: een onderschat milieuprobleem (an underestimated environmental problem). S. Knijff, P. Meulenberg.
  • 1996 STOWA Report 96-25: Indicative analytical methods and group- and sum-para¬meters for the determination of water quality; Survey of existing techniques and correlation analyses of water quality.
  • 1997 Phenylurea herbicides screening in the Rhine. In order of WRK in Nieuwegein, the Netherlands. Report nr. 2.
  • 1997 Phenylurea herbicides screening in the Rhine. In order of WRK in Nieuwegein, the Netherlands. Report nr. 3.
  • 1997 STOWA Report 97-09: Indicative analytical methods and group- and sum-para¬meters for the determination of water quality; Validation of the selected techniques.
  • 1997 Immunoaffinity chromatography of pesticides: Final report in the scope of PBTS-funding.
  • 1997 Feasibility study for the development of Multi Analyte Immunoassays. Report in the scope of a Exploratory Award (EU, Brussels).
  • 1997 STOWA Report 97-04: Indicative analytical methods and group- and sum-para¬meters for the determination of water quality; Evaluation of the immunoassay method as a indicative en quantitative method.
  • 1998 Phenylurea herbicides screening in the Rhine. In order of WKR in Nieuwegein, the Netherlands. Rapport nr. 4.
  • 1999 Phenylurea herbicides screening in the Rhine. In order of WRK in Nieuwegein, the Netherlands. Rapport nr. 5.
  • 1999 Phenylurea herbicides screening in the Rhine. In order of WRK in Nieuwegein, the Netherlands. Rapport nr. 6.
  • 2000 Phenylurea herbicides screening in the Rhine. In order of WRK in Nieuwegein, the Netherlands. Rapport nr. 7.
  • 2000 Determination of microcystines in surface water and floating layers by immunoassay. Report in order of the Ministry of Traffic and Water affairs, Director-General Rijkswaterstaat, Management Zeeland, the Netherlands.
  • 2001 Determination of microcystines in surface water and floating layers by immunoassay. Report in order of the Ministry of Traffic and Water affairs, Director-General Rijkswaterstaat, Management Zeeland, the Netherlands.
  • 2001 Phenylurea herbicides screening in the Rhine. In order of WRK in Nieuwegein, the Netherlands. Rapport nr. 8.
  • 2002 Determination of microcystines in surface water and floating layers by immunoassay.Report in order of the Ministry of Traffic and Water affairs, Directoraat-General Rijkswaterstaat, Management Zeeland, the Netherlands.
  • 2003 Determination of microcystines in surface water and floating layers by immunoassay. Report in order of the Ministry of Traffic and Water affairs, Directoraat-General Rijkswaterstaat, Management Zeeland, the Netherlands.
  • 2004 Determination of microcystines in surface water and floating layers by immunoassay. Report in order of the Ministry of Traffic and Water affairs, Directoraat-General Rijkswaterstaat, Management Zeeland, the Netherlands.
  • 2005 Determination of microcystines in surface water and floating layers by immunoassay. Report in order of the Ministry of Traffic and Water affairs, Directoraat-General Rijkswaterstaat, Management Zeeland, the Netherlands.
  • 2006 Biosensor screening of surface water samples for thyroid hormone-like activity. Report in order of the Association of Rhine Water Works, Nieuwegein.
  • 2006 Relevance of the assessment of thyroidal activity in the (water)environment: A deskresearch. Report in order of the Association of Rhine Water Works, Nieuwegein.
  • 2006 Biosensor screening of surface water samples for thyroid hormone-like activity. Report in order of the Association of Rhine Water Works,Nieuwegein.
  • 2006 Relevance of the assessment of thyroidal activity in the (water)environment: A deskresearch. Report in order of the Association of Rhine Water Works, Nieuwegein.
  • 2007 Endocrine disrupting compounds in the environment. Invited book chapter, submitted.
  • 2007 Deskresearch Immunosensor and antibodies, for Optisense, Enschede.
  • 2007 Protocols for the development and validation of an immunoassay, for Optisense, Enschede.
  • 2008 Script for antibody selection for biosensor application, for Optisense, Enchede.

Projecten:

  • 1993 Usefulness of cyclodextrines for extraction/detectionpurposes:
    Regarding cyclodextrines, namely ß-cyclodextrine, a preliminary investigation was conducted to check whether these compounds were useful for the extraction and/or detection of environmental polluting substances from aqueous samples.
  • 1993 Evaluation of immunoassay kits for 2,4-D:
    In 1993 an evaluation investigation was conducted, in order of WRK (Drinking Water Company Rijn-Kennemerland) in Nieuwegein (The Netherlands) regarding the applicability of commercially available immunoassays kits to analyse 2.4-dichloro-phenoxy acetic acids in surface water.
  • 1994 Applicability of the immunoassay for 2,4-D
    In continuation of the above evaluation investigation, again in order of the WRK, a commercially available immunoassay kit was applied in an “early warning”-program. During 10 months samples from Rhine water were collected daily to batchwise analyse them by the kit. The objective was the early detection of any possible concentration decrease of 2.4-D in the river Rhine.
  • 1994 Immunochemical detection of isoproturon:
    During a period of relatively increased concentrations of isoproturon in the river Rhine, in a number of water samples the concentra¬tion of isoproturon was analysed by a commercial available immu¬noassay. The results were compared with the reference assays that were conducted by WRK.
  • 1995 Immunochemical detection of phenylurea herbicides:
    In order of the WRK, two commercially available immunoassay kits for phenylurea herbicides were tested. One is specific for isoproturon, the other provides a sum parameter for this group of compounds. In springtime Rhine water samples will be measured on a regular basis during several months with both of the kits. These projects were conducted in 1995 – 2002.
  • 1995 The Development of immunoaffinity columns for pesticides:
    In cooperation with WRK, RIZA, KIWA and J.T. Baker efforts are being made for the development of IAC-columns for the extraction, purification and concentration of pesticides from surface water. For multiple target compounds various antibodies were linked to various supports. The developed columns were tested and evaluated; measuring was done by immunoassay, HPLC en GC.
  • 1995 Solid Phase Extraction (SPE) of PAH:
    For the extraction of PAH from aqueous samples the feasibility of extraction using disks was tested. The use of extraction disks should lead to more efficient collection, extraction and storage of samples.
  • 1995 Investigation into indicative methods and group and sum parameters:
    Project in cooperation with ICWS (Amsterdam), KIWA (Nieuwegein), RIVM (Bilthoven) en Aquasens (Amsterdam). This investigation was financed by STOWA. Investigation into promising indicative analyse techniques for the quality control in water management. After desk research, the most promising methods were evaluated and validated in comparison to the classical methods of reference on laboratory level. Than the tested methods were applied in a number of investigation projects and carried out by the laboratories of the water management companies. The results were published in 3 different successive STOWA rapports.
  • 1997 On-line detection of pesticides in surface water:
    In cooperation with Isogen B.V. (Maarssen) and WRK (Nieuwegein), an on-line detection system for pesticides is developed. In this method immunoaffinity columns are used for selective extraction of the target compounds. This project is carried out within the scope of a BTS-grant.
  • 1998 Phage Display Technique for production of antibodyfragments:
    In cooperation with KUN (Nijmegen) and Future Diagnostics B.V. (Wijchen) investigations will be conducted for the possibility of the application of Phage Display Technique for the production of antibody fragments. These fragments shall be used for the development of immunoassays and immunoaffinity columns for detection en quantifying pesticides, vitamine D and renine. Further, in the scope of this project, polyclonale as well as monoclonal antibodies will be produced, for use in ELISA as well as IAC. This project has been conducted within the scope of a BTS-grant.
  • 1999 Development of Multi Analite Immunoassays en Immunosensors:
    In cooperation with Microgen Ltd. (G.B.), Waterlaboratory Edam and TNO (Zeist) investigation is directed for the development of Multi Analyte Immunoassays for the simultaneous measurement of various pesticides. Using the same materials an immunosensor for field application will be developed. The format of the MAI will be an ELISA or a FIA on a microtiterplate. The application will initially be directed on screening of pesticides in water samples in the scope of water quality management. In addition, the assay will be adapted to measurements in foods. The immunosensor to be developed initially will be developed for the rapid field measurement of groups of organophosphate pesticides. This project is carried out within the scope of a EC-grant (Craft).
  • 1999 Development of a test for estrogenic activity of environmental contaminants:
    In the scope of an international research into the biological activity of environmental contaminants ELTI Support did the part concerning estrogenic activity. For this purpose an assay will be developed, for rapid analysis of an estrogenic activity from a certain compound based on its activity for hormone-binding protein (SHBG) from human blood. This assay is similar to ELISA in that displacement of an enzyme tracer from the binding protein by the compound to be measured is used. (This is part of a patent application).
  • 2000-2003 IAC-OESA:
    Immunoaffinity chromatography in combination with an estrogenic as¬say/sensors for the determination of van estrogenic activity of environmental contaminants. Project in cooperation with Rikilt (Wageningen), Merksa (Groningen), ResQ Lab (Nijeveen) and Analytical Devices (Zeist). Groups of environmental contaminants will be isolated from water samples by IAC and then screened for estrogenic activity using a receptor sensor and the SHBG-assay. Optionally a receptor column is inserted in this design. This project is carried out within the scope of a BTS-grant.
  • 2000-2003 Determination of microcystines using immunoassays in swimming water in the Province of Zeeland.
    Project in order of the Province of Zeeland in the years 2000, 2001, 2002 en 2003. In this project the presence and concentration of microcystines in swimming water is determined by immunoassay kits to ensure the water quality for recreation.
  • 2002-2005 Development of Affinity-based Biochemical Tests for Detection of Pollutants in Water.
    Research into antibody and receptor affinity-based biochemical tests (affinity columns, bioassays and sensors) for qualitative analysis of water samples. Target compounds include pesticides, toxins and pharmaceutical substances showing hormone disrupting activity. Project in the scope of Marie Curie Host Fellowship. Preformed by G. Marchesini as Ph.D. study.
  • 2005 Investigation into the feasibility of bioassays for endocrine disruptors:
    thyroids and corticosteroids. In cooperation with Rikilt Institute and Analytical Devices. Aim of this investigation is the development of rapid sensitive bio(sensor)assays for the assessment of thyroid and corticosteroid activity in water and food samples using hormone binding proteins from human blood.
  • 2005 Investigation into the feasibility of bioassays for endocrine disruptors: thyroids and corticosteroids. In cooperation with Rikilt Institute and Analytical Devices. Aim of this investigation is the development of rapid sensitive bio(sensor)assays for the assessment of thyroid and corticosteroid activity in water and food samples using hormone binding proteins from human blood.
  • 2007 Development of an MZI immune sensor for the detection of environmental pollutants. In cooperation with Optisense, Enschede.
  • 2009 Ontwikkeling van een biosensor voor microcystines. In samenwerking met Analytic Devices, Zeist. Gesubsidieerd door EZ in het kader van het SBIR programma. Er zal een antilichaam-gebaseerd biosensor met fluorescentiedetectie worden ontwikkeld voor de meting van microcystines in water.
  • 2010 Ontwikkeling van een biosensor voor thuisgebruik voor progesteron. In samenwerking met Analytic Devices, Zeist, en Genium Groep, Nijmgen. Er zal een antilichaam-gebaseerde biosensor met fluorescetiedetectie worden ontwikkeld voor de meting van progesteron in speeksel tijdens de zwangerschap.
  • 2010 Ontwikkeling van een assay voor 11ß-HSD1-activiteit. In samenwerking met de Universiteit van Stuttgart, Duitsland. Het enzym 11ß-HSD1 zal worden geïsoleerd uit genetisch gemodificeerde Pichia pastoris en worden gebruikt voor het ontwikkelen van een assay voor het vaststellen van de invloed van milieurelevante verbindingen op de activiteit van dit enzym in het kader van onderzoek naar obesitas.